The CADM1 (Cell adhesion molecule 1, Tumor suppressor in lung cancer 1; TSLC1, IgSF4, Necl2, Syncam or

SgIGSF) gene encodes an immunoglobulin (Ig) superfamily cell adhesion molecule (IgCAM). CADM1 is a well-known tumor suppressor gene in a variety of human cancers, particularly those of epithelial cell origin, including liver, pancreatic and prostate cancers. This gene is generally inactivated in these carcinomas via 2 mechanisms; promoter methylation and/or loss of heterozygosity at the gene locus. 1 The CADM1 gene encodes a 442-amino acid class I membrane protein and contains three Ig loops in the extracellular domain, a transmembrane domain and a short cytoplasmic domain. 2 This primary structure is also observed in IgCAM protein family