Ovarian failure following abdominal irradiation in childhood: natural history and prognosis
WHB Wallace, SM Shalet, EC Crowne… - Clinical oncology, 1989 - Elsevier
Ovarian function has been reviewed sequentially since 1975 in 53 patients treated in
childhood between 1942 and 1985 for an intra-abdominal tumour with surgery and external
abdominal radiotherapy (XRT). Of 38 patients who received whole abdominal XRT (20–30
Gy), 27 failed to undergo or complete pubertal development (pubertal failure) and a
premature menopause (median age 23.5 years) occurred in a further ten. Of 15 patients who
received flank XRT (20–30 Gy), ovarian function (median age at last assessment 15.2 years) …
childhood between 1942 and 1985 for an intra-abdominal tumour with surgery and external
abdominal radiotherapy (XRT). Of 38 patients who received whole abdominal XRT (20–30
Gy), 27 failed to undergo or complete pubertal development (pubertal failure) and a
premature menopause (median age 23.5 years) occurred in a further ten. Of 15 patients who
received flank XRT (20–30 Gy), ovarian function (median age at last assessment 15.2 years) …
